v. 1. The beginnings of philosophy.--v. 2. The Eleatics and pluralists.

We investigate how the perceived uncertainty of a conditional affects a person's choice of conclusion. We use a novel procedure to introduce uncertainty by manipulating the conditional probability of the consequent given the antecedent. In Experiment 1, we show first that subjects reduce their choice of valid conclusions when a conditional is followed by an additional premise that makes the major premise uncertain. In this we replicate Byrne. These subjects choose, instead, a qualified conclusion expressing uncertainty. If subjects are (...) given a third statement that qualifies the likelihood of the additional premise, then the uncertainty of the conclusions they choose is systematically related to the suggested uncertainty. Experiment 2 confirms these observations in problems that omit the additional premise and qualify the first premise directly. Experiment 3 shows that the qualifying statement also affects the perceived probability of the consequent given the antecedent of the conditional. Experiment 4 investigates the effect of suggested uncertainty on the fallacies and shows that increases in uncertainty reduce the number of certain conclusions that are chosen while affirming the consequent but have no effect on denying the antecedent. We discuss our results in terms of rule theories and mental models and conclude that the latter give the most natural account of our results. (shrink)

It is often argued that human emotions, and the cognitions that accompany them, involve refinements of, and extensions to, more basic functionality shared with other species. Such refinements may rely on common or on distinct processes and representations. Multi-level theories of cognition and affect make distinctions between qualitatively different types of representations often dealing with bodily, affective and cognitive attributes of self-related meanings. This paper will adopt a particular multi-level perspective on mental architecture and show how a mechanism of subsystem (...) differentiation could have allowed an evolutionarily “old” role for emotion in the control of action to have altered into one more closely coupled to meaning systems. We conclude by outlining some illustrative consequences of our analysis that might usefully be addressed in research in comparative psychology, cognitive archaeology, and in laboratory research on memory for emotional material. (shrink)

Language employs various coordinators to connect propositions, a subset of which are “logical” in nature and thus analogous to the truth operators of formal logic. We here focus on two linguistic connectives and their negations: conjunction _and_ and (inclusive) disjunction _or_. Linguistic connectives exhibit a truth-conditional component as part of their meaning (their semantics), but their use in context can give rise to various implicatures and presuppositions (the domain of pragmatics) as well as to inferences that go beyond semantic/pragmatic properties (...) (the result of reasoning processes). We provide a comprehensive review of the role of the logical connectives in language and argue that three sets of factors—semantic, pragmatic, and those related to reasoning—are separate and separable, though some details may differ cross-linguistically. As a way to showcase the argument, we present two experiments in language comprehension in Spanish wherein pragmatic content was minimised and reasoning processes neutered, thus potentially highlighting what might be the default meanings of the connectives under study. In Experiment 1 we show that the conjunctive reading of inclusive disjunction is available in positive contexts other than in syntactically intricate cases such as downward entailing and free choice contexts, contrary to what has been claimed in the literature. In Experiment 2 we show that negated conjunctions and disjunctions in Spanish can easily receive the same interpretation when contrasted against the same context and, moreover, that these interpretations match those available in English, despite claims from the literature that linguistic connectives and local negation interact differently in English and Romance languages. (shrink)

Regulation of the cytoplasmic stability of mRNAs has recetly been identified as a major control mechanism which governs mRNA levels in a variety of eukaryotic systems. In this review we discuss what is known about several experimental systems that exhibit regulated mRNA stability, describe the mechanisms that cells may use to achieve control of mRNA degradation, and suggest areas of future investigation likely to provide new insights into this process.

The diploblastic Cnidaria form one of the most ancient metazoan phyla and thus provide a useful outgroup for comparative studies of the molecular control of development in the more complex, and more often studied, triploblasts. Among cnidarians, the reef building coral Acropora is a particularly appropriate choice for study. Acropora belongs to the Anthozoa, which several lines of evidence now indicate is the basal class within the phylum Cnidaria, and has the practical advantages that its reproduction is predictable, external and (...) accessible and that the base content of its genome is not strongly biased. The Acropora system has already provided insights into ancestral linkages of homeobox genes and the evolution of the Pax genes, and has the potential to provide further new perspectives on the age, role in development, and evolution of these and other gene families. BioEssays 22:291–296, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Combining two thoughts into a compound mental representation is a central feature of our verbal and non-verbal logical abilities. We here approach this issue by focusing on the contingency that while natural languages have typically lexicalised only two of the possible 16 binary connectives from formal logic to express compound thoughts—namely, the coordinatorsandandor—some of the remainder appear to be entertainable in a non-verbal, conceptual representational system—alanguage of thought—and this suggests a theoretical split between the “lexicalisation” of the connectives and the (...) “learnability” of invented words corresponding to unlexicalised connectives. In avisual worldexperiment aimed at tracking comprehension-related as well as reasoning-related aspects of the capacity to represent compound thoughts, we found that participants are capable of learning and interpreting a made-up word standing for logic's NAND operator, a result that indicates that unlexicalised logical connectives are not only conceptually available, but can also be mapped onto new function words, as in the case of coordinators, or connectives, a class of words that do not usually admit new coinages. (shrink)

Language’s intentional nature has been highlighted as a crucial feature distinguishing it from other communication systems. Specifically, language is often thought to depend on highly structured intentional action and mutual mindreading by a communicator and recipient. Whilst similar abilities in animals can shed light on the evolution of intentionality, they remain challenging to detect unambiguously. We revisit animal intentional communication and suggest that progress in identifying analogous capacities has been complicated by (i) the assumption that intentional (that is, voluntary) production (...) of communicative acts requires mental-state attribution, and (ii) variation in approaches investigating communication across sensory modalities. To move forward, we argue that a framework fusing research across modalities and species is required. We structure intentional communication into a series of requirements, each of which can be operationalised, investigated empirically, and must be met for purposive, intentionally communicative acts to be demonstrated. Our unified approach helps elucidate the distribution of animal intentional communication and subsequently serves to clarify what is meant by attributions of intentional communication in animals and humans. (shrink)

This chapter contains sections titled: Introduction1 The Problem Arguments Against Materialism Type‐A Materialism Type‐B Materialism15 The Two‐Dimensional Argument Against Type‐B Materialism Type‐C Materialism Interlude Type‐D Dualism Type‐E Dualism Type‐F Monism Conclusions.

This paper is an edited transcription of a talk at the 1997 Montreal symposium on "Consciousness at the Frontiers of Neuroscience". There's not much here that isn't said elsewhere, e.g. in "Facing Up to the Problem of Consciousness" and "How Can We Construct a Science of Consciousness?"]].

This book is a collection of papers presented at an interdisciplinary workshop at the Calgary Institute for the Humanities in May 1980. The three broad issues covered are: the physician-patient relationship, the allocation of responsibility among doctors and nurses, and the political and social framework of the health care system. The first set of essays is concerned with the moral and legal aspects of the physician-patient relationship. The link between knowledge and power is examined as well as the moral dilemmas (...) posed by medical technology. These initial essays would alone justify this publ. (shrink)

Deep brain stimulation of the subthalamic nucleus is a clinically effective tool for treating medically refractory Parkinson’s disease, but its neural mechanisms remain debated. Previous work has demonstrated that STN DBS results in evoked potentials in the primary motor cortex, suggesting that modulation of cortical physiology may be involved in its therapeutic effects. Due to technical challenges presented by high-amplitude DBS artifacts, these EPs are often measured in response to low-frequency stimulation, which is generally ineffective at PD symptom management. This (...) study aims to characterize STN-to-cortex EPs seen during clinically relevant high-frequency STN DBS for PD. Intraoperatively, we applied STN DBS to 6 PD patients while recording electrocorticography from an electrode strip over the ipsilateral central sulcus. Using recently published techniques, we removed large stimulation artifacts to enable quantification of STN-to-cortex EPs. Two cortical EPs were observed – one synchronized with DBS onset and persisting during ongoing stimulation, and one immediately following DBS offset, here termed the “start” and the “end” EPs respectively. The start EP is, to our knowledge, the first long-latency cortical EP reported during ongoing high-frequency DBS. The start and end EPs differ in magnitude and latency, and the end, but not the start, EP magnitude has a significant relationship to ongoing high gamma power during the EP. These contrasts may suggest mechanistic or circuit differences in EP production during the two time periods. This represents a potential framework for relating DBS clinical efficacy to the effects of a variety of stimulation parameters on EPs. (shrink)

This paper argues that the Food and Drug Administration’s (FDA) policy for health and wellness apps is ethically problematic. Currently, the FDA does not regulate health and wellness apps that are not intended for medical use. As a result of this hands‐off policy, preventing harm to consumers is left primarily to developers and app marketplaces. We argue that the FDA’s duties to prevent harm and maintain accountability to the American public require that they play a much stronger role. We also (...) discuss concerns about efficiency and fostering innovation, and argue that while they should help shape FDA regulation of health and wellness apps, they do not justify complete absence of FDA involvement. -/- . (shrink)

Evolutionary psychologists sometimes suggest that "an evolutionary view of life can shed light on psyche" by revealing the "latent" psychology that underlies our "manifest" psychological image. At such moments, which become more frequent in popular works, explanations trade freely in subconscious motives whose goal is inclusive fitness. While some evolutionary psychologists explicitly deny that their aim is to uncover latent motivation, references to subconscious motives are nonetheless frequent in evolutionary psychology (and are even made by those explicitly denying postulation of (...) subconscious motives). These explanatory references to subconscious motives pose a dilemma. On the one hand, if they are literal, evolutionary psychology is vulnerable to a criticism frequently leveled against sociobiology: if subconscious motives toward inclusive fitness are the true determinants of human behavior, our behavior should more closely approximate full satisfaction of those motives (i.e. increased fitness) than it does. On the other hand, if references to subconscious motives are merely figurative -- like talk of "selfish" genes -- it must be explained how they are to be literally interpreted. Either way it is necessary to "deFreud" evolutionary psychology. I will thus provide an account of evolutionary psychological explanation, and how it functions, when purged of reference to subconscious motives. (shrink)

One often hears it said that our visual-perceptual contact with the world is “perspectival.” But this can mean quite different things. Three different senses in which our visual contact with the world is “perspectival” are distinguished. The first involves the detection or representation of behaviorally important relations, holding between a perceiving subject and the world. These include time to contact, body-scaled size, egocentric position, and direction of heading. The second perspective becomes at least explicitly manifest in taking up the “proximal (...) mode” and involves the representation of relational “appearance properties,” such as, perhaps , angular size and angular/projective shape at or from a viewpoint. The third perspective is associated with the pencil of rays structured by the position and geometry of the eyes. The relationships between these three perspectives are charted, and their connection with conscious experiential awareness discussed. So, e.g., there is no simple or direct route from the detection of the relations constitutive of perspective2 to detection of the relations constitutive of perspective1. The relations definitive of perspective3 are probably not themselves detected or represented by the visual system, but define the informational arena within which detection of the relations definitive of perspective1 and perspective2 takes place. (shrink)

Recognition that biological systems are stabilized far from equilibrium by self-organizing, informed, autocatalytic cycles and structures that dissipate unusable energy and matter has led to recent attempts to reformulate evolutionary theory. We hold that such insights are consistent with the broad development of the Darwinian Tradition and with the concept of natural selection. Biological systems are selected that re not only more efficient than competitors but also enhance the integrity of the web of energetic relations in which they are embedded. (...) But the expansion of the informational phase space, upon which selection acts, is also guaranteed by the properties of open informational-energetic systems. This provides a directionality and irreversibility to evolutionary processes that are not reflected in current theory.For this thermodynamically-based program to progress, we believe that biological information should not be treated in isolation from energy flows, and that the ecological perspective must be given descriptive and explanatory primacy. Levels of the ecological hierarchy are relational parts of ecological systems in which there are stable, informed patterns of energy flow and entropic dissipation. Isomorphies between developmental patterns and ecological succession are revealing because they suggest that much of the encoded metabolic information in biological systems is internalized ecological information. The geneological hierarchy, to the extent that its information content reflects internalized ecological information, can therefore be redescribed as an ecological hierarchy. (shrink)

Millikan and Wilson argue, for different reasons, that the essential reference to the environment in adaptationist explanations of behavior makes (psychological) individualism inconsistent with evolutionary psychology. I show that their arguments are based on misinterpretations of the role of reference to the environment in such explanations. By exploring these misinterpretations, I develop an account of explanation in evolutionary psychology that is fully consistent with individualism. This does not, however, constitute a full-fledged defense of individualism, since evolutionary psychology is only one (...) explanatory paradigm among many in psychology. (shrink)

John Reiss is a practicing evolutionary biologist (herpetology) who by his own account happened to be in the right place (Harvard’s Museum of Comparative Zoology) at the right time (the 1980s) to hear echoes of the debate about sociobiology that had been raging there between E. O. Wilson and, on the other side, Stephen Jay Gould and Richard Lewontin (xiv). Reiss is not concerned with sociobiology, at least in this book, but with the adaptationism that Gould and Lewontin saw in (...) the sociobiologists’ approach to cooperative behavior. At Harvard, Reiss was guided by Pere Alberch, in whose laboratory Gould’s stress on developmental constraints was being transformed into a now influential version of the Evo-devo movement (xiv, 327). On Alberch’s view, which Reiss accepts, variation in the rate, timing, placement, and intensity of gene products during the ontogenetic process, rather than mutation in structural genes, constitutes the proximate source of the phenotypic variation on which natural election works (327-29). Reiss does not think that Evo-devo, at least as he construes it, does away with natural selection. Rather, he seeks to identify the role played by selection in retaining or eliminating the variation generated in the developmental process. Selection, he argues, enables organisms, populations, species, and other lineages to maintain the presumptively adapted conditions of existence to which their very persistence already testifies. “Adaptedness,” Reiss writes, “is not a product of evolution; it is a condition for evolution” (22). He thinks that this fact, as he takes it to be, belies the adaptationist assumption that organisms are collections of independently optimal adaptations that arise by way of concerted spurts of directional selection. “It is a mistake,” he writes, “to atomize organisms and to explain each part as the solution of a problem raised by the environment” (295). (shrink)

thought and problem solving in persons lacking natural language altogether would be a decisive challenge, but there is no clear evidence of any abstract thinking capabilities similar to those evinced by the scientists. Pinker cites languageless persons rebuilding broken locks - this is evidence of perhaps visual imagery, but not mentalese (at least not without quite a bit more detail and argument than we are given). Spiders, e.g., build marvelous things, but no inference to spiderese appears to be warranted. There (...) simply is much we don. (shrink)

Discussion of Fodor's doctrine of 'methodological solipsism' and Stich's principle of autonomy' has been concerned to show that these principles are incompatible with psychological theories which appeal to states with content (e.g. beliefs and desires). Concern with these issues, and the subsequent attempt to develop a notion of 'narrow' content which is solipsistic or autonomous, has, I believe, obscured a more fundamental issue: No theory which satisfies these principles would ever be able to explain behavior under descriptions which are in (...) fact important to psychology. But I do not simply argue that there are descriptions under which psychological theories will not in fact explain behavior; I argue that descriptions under which psychological theories do explain behavior are not compatible with solipsistic principles. I develop several thought experiments to demonstrate this. (shrink)

In our 2016 paper (Collins et al., 2016a), we proposed that superchamps (athletes who have achieved the highest level in their sport) were differentiated from their less successful counterparts by their use of positive proactive coping and a “learn from it” approach to challenge. This skill-based focus to talent development (TD) is supported extensively in the literature (e.g., MacNamara et al., 2010a, 2010b) and suggests that the differences between levels of adult achievement relate more to what performers bring to the (...) challenges than what they experience (Collins et al., 2016a). In this focused review we present and discuss a number of key concepts related to this paper and other parallel research in TD. We begin by presenting our pragmatic objectives and the importance of considering how we evaluate the research with an emphasis on its application to the applied setting. We then consider commonalities and differences in recent psychological approaches to TD, namely the experiential, attitudinal and skill-based. The paper then provides further exploration of the Psychological Characteristics of Developing Excellence and their role in TD processes. We conclude with a consideration of future research and the application of research in TD. Reflecting our pragmatic stance as researchers, we hope that this focused review provides suggestions for progress and stimulates critical debate amongst practitioners, researchers and policy makers. (shrink)

A collection of personal narratives and essays, Living Professionalism is designed to help medical students and residents understand and internalize various aspects of professionalism. These essays are meant for personal reflection and above all, for thoughtful discussion with mentors, with peers, with others throughout the health care provider community who care about acting professionally.

The ease with which genotyping technologies generate tremendous amounts of data on research participants has been well chronicled, a feat that continues to become both faster and cheaper to perform. In parallel to these advances come additional ethical considerations and debates, one of which centers on providing individual research results and incidental findings back to research participants taking part in genetic research efforts. In 2006 the Industry Pharmacogenomics Working Group offered some ‘Points-to-Consider’ on this topic within the context of the (...) drug development process from those who are affiliated to pharmaceutical companies. Today many of these points remain applicable to the discussion but will be expanded upon in this updated viewpoint from the I-PWG. The exploratory nature of pharmacogenomic work in the pharmaceutical industry is discussed to provide context for why these results typically are not best suited for return. Operational challenges unique to this industry which cause barriers to returning this information are also explained. (shrink)

For over half a century there have been concerns about increases in the occurrence of academic misconduct by higher education students and this is now claimed to have reached crisis proportions (e.g. Mostrous & Kenber, 2016a ). This study explores the extent to which multi-national faculty judge the effectiveness of higher education institutions in dealing with such misconduct. A survey of multi-national higher education faculty was conducted to explore the perceived barriers to the implementation of academic integrity processes. It asked (...) faculty how likely some hypothetical scenarios of failures of such processes were to occur in the real world of higher education institutions. 63% of our participants perceived there to be institutional and/or faculty barriers to effectively dealing with academic misconduct. Mostly, they blamed the higher education model for this which, in the interests of mass education, has come to prioritise the need for institutions to focus more on their quantity of output as corporate business enterprises than on the integrity of their output as educators. In discussing participants’ comments, about the relationship of faculty to their employing institutions, Schein and Scheins’ ( 2016 ) theory of three levels of organisational culture was used. Participants’ comments suggested that, at the deepest level of organisational culture i.e. basic underlying taken-for-granted assumptions about beliefs and values, inadequate integrity measures have tended to become normalised. Despite the often considerable, efforts of the institutions, organisational barriers were noted which mitigate against faculty behaving professionally i.e. from doing a ‘good job’ in respect of student academic misconduct. Some blame was also placed on faculty. We argue that apparent institutional inability to effectively manage the integrity process, has potentially significant consequences for wider society. We discuss ways in which this situation might be improved including a recommendation that governments regulate this aspect of the corporate social responsibility of higher education institutions as they do other aspects, requiring that it be managed effectively. (shrink)

Suicide has been condemned in our culture in one way or another since Augustine offered theological arguments against it in the sixth century. More recently, theological condemnation has given way to the view that suicidal behavior must always be symptomatic of emotional disturbance and mental illness. However, suicide has not always been viewed so negatively. In other times and cultures, it has been held that circumstances might befall a person in which suicide would be a perfectly rational course of action, (...) in the same sense that any other course of action could be rational: that it could be sensible, i.e., defensible by good reasons, or that it could be in keeping with the agent's fundamental interests. Indiscriminate use of modern life-sustaining technologies has renewed interest in the possibility of rational suicide. Today proponents of rational suicide tend to equate the rationality of suicide with the competence of the decision to commit suicide. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 11.1 (2004) 55-64 [Access article in PDF] Delusions and Discourse:Moving beyond the Constraints of the Modernist Paradigm David J. Harper This special issue provides a good opportunity to reflect on the range of views about delusions,1 and it is good to see all the authors taking the issue of how to approach this topic seriously. Here I wish to argue that the traditional psychiatric (...) view of delusions is problematic. In the first half of this article I will group my comments on the issues raised by the papers by Klee and Bayne and Pacherie together as I think that, for their differences, they share modernist philosophical assumptions. I will argue that the modernist paradigm runs into considerable problems in considering beliefs felt by some to be unusual and I will go on to argue that we need to move beyond this paradigm and embrace different approaches, of which the work by Georgaca is an exemplar. The Trouble with (traditional Views of) Delusions The traditional psychiatric view of delusion has come under increasing attack over recent years. As Georgaca has noted, a number of problems with the assumptions in definitions of delusion can be identified when they are viewed from a social constructionist perspective (Georgaca 2000, 2004; Harper 1992, 1996; Heise 1988). For convenience I will group these under four main headings. They Are Based on a Naively Realist View of the World The criterion of inaccuracy or falsity implies that deciding on the veracity of a belief is a relatively unproblematic matter. However, the reality of claims does not always seem so important in judgments about whether a belief is delusional or not. For example, there is little evidence that mental health professionals systematically investigate the basis for people's beliefs; rather, they decide whether a belief is plausible. Thus Maher has argued that the assessment of the plausibility of beliefs is "typically made by a clinician on the basis of "common sense," and not on the basis of a systematic evaluation of empirical data" (1992, 261). He notes that it is not "customary to present counterevidence to the patient; it is not even common to present vigorous counterargument" (1992, 261) and there appears to be some empirical evidence of this (McCabe et al. 2002). Here then, we begin to see [End Page 55] how psychiatry, while claiming to have the power to judge the truth of beliefs on the basis of its status as an empirical scientific discipline, can be seen to make judgments on the basis of common sense and taken-for-granted social and cultural assumptions.Some commentators have suggested that delusions should be identified less by whether they seem to accord with reality but more by whether a person gives evidence for their belief (Gillett 1995; Spitzer 1990). However, this seems to be based on an idealized view of how people manage their beliefs in everyday life. For example, I would question how many of us have evidence for many of the beliefs (e.g., political, ethical, religious, etc.) we hold dear; indeed it would be hard to think of what evidence we could have for some of them (e.g., religious and ethical beliefs). Some recent work has suggested that the diagnosis of delusion is made on the basis of how people with delusions talk and interact; for example, some have argued that they do not appear to appreciate the hearer's point of view (Palmer 2000). However, here and in previous work, Georgaca (2000, 2004) has shown that people with delusions are able to talk about and negotiate disagreements about their beliefs and that many disputes of fact cannot be settled in conversation. People Said to Have Delusions Are Seen to Vary in the Conviction With Which Those Beliefs Are Held There is evidence that people considered to be deluded vary in the conviction with which they hold beliefs (Garety 1985) and can also be persuaded to modify their beliefs if this is conducted in a sensitive and collaborative manner (e.g., Chadwick, Birchwood, and Trower 1996). This... (shrink)

Despite the salient experience of encoding threatening events, these memories are prone to distortions and often non-veridical from encoding to recall. Further, threat has been shown to preferentially disrupt the binding of event details and enhance goal-relevant information. While extensive work has characterised distinctive features of emotional memory, research has not fully explored the influence threat has on temporal memory, a process putatively supported by the binding of event details into a temporal context. Two primary competing hypotheses have been proposed; (...) that threat can impair or enhance temporal memory. We analysed two datasets to assess temporal memory for an in-person haunted house experience. In study 1, we examined the temporal structure of memory by characterising memory contiguity in free recall as a function of individual levels of heart rate as a proxy of threat. In study 2, we replicated marginal findings of threat-related increases in memory contiguity found in study 1. We extended these findings by showing threat-related increases in recency discriminations, an explicit test of temporal memory. Together, these findings demonstrate that threat enhances temporal memory regarding free recall structure and during explicit memory judgments. (shrink)